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Synthesis and antibacterial activity of new poly-S-lysine-porphyrin conjugates.

Tomé JP, Neves MG, Tomé AC, Cavaleiro JA, Soncin M, Magaraggia M, Ferro S, Jori G

Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.

Studies on the synthesis, structural elucidation, and biological evaluation of new conjugates of poly-S-lysine with meso-substituted porphyrins are described. The new conjugates were used in the photoinactivation of antibiotic-resistant Gram-positive bacteria (Staphylococcus aureus strains ATCC 25923 and MRSA 110) and Gram-negative bacteria (Escherichia coli strain O4). The results show that the cationic conjugates are able to photosensitize the efficient inactivation of both types of bacteria.

Published 13 December 2004 in J Med Chem, 47(26): 6649-52.
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