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Distribution of major genotypes among methicillin-resistant Staphylococcus aureus clones in Asian countries.

Ko KS, Lee JY, Suh JY, Oh WS, Peck KR, Lee NY, Song JH

Sungkyunkwan University School of Medicine Asian-Pacific Research Foundation for Infectious Diseases, 50 II-won dong, Kangnam-ku, Seoul 135-710, Korea.

To investigate the evolutionary pattern and genotypic characteristics of methicillin-resistant Staphylococcus aureus (MRSA) strains in the Asian region, 74 MRSA strains isolated from 12 Asian countries were analyzed by multilocus sequence typing (MLST) and SCCmec typing. Overall, a total of 16 genotypes based on sequence type and SCCmec types were identified among MRSA strains from Asian countries. Data revealed two major genotypes of MRSA strains in Asia, with unique geographic distributions. By MLST analysis, all strains from Korea and Japan except one belonged to clonal complex 5 (CC5) while most MRSA isolates from other Asian countries belonged to CC239. SCCmec typing showed that most isolates from Korea and Japan were SSmec type II whereas SCCmec type III (or IIIA) was the most common type in strains from other Asian countries. Our data documented a unique geographic distribution and evolutionary pattern of MRSA clones in Asia.

Published 6 January 2005 in J Clin Microbiol, 43(1): 421-6.
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