MRSA Research Today is a free monthly online journal that collates and summarizes the latest research about MRSA, including details on methicillin-resistant staphylococcus aureus, hospitals, infection, antibiotic resistance, superbugs.

Synthesis and structure-activity relationships of 2-vinylchroman-4-ones as potent antibiotic agents.

Albrecht U, Lalk M, Langer P

Institut für Chemie und Biochemie, Ernst-Moritz-Arndt-Universität, Soldmannstr. 16, D-17487 Greifswald, Germany.

A series of novel 2-vinylchroman-4-ones, analogues of the natural products Aposphaerin A and B, were identified as potent antibiotics. Derivatives exhibit a significant activity against multiresistant strains of S. aureus, such as MRSA (methicillin resistant S. aureus). The 2-vinylchroman-4-ones were efficiently prepared by Lewis acid mediated conjugate addition of vinylmagnesium bromide to chromones.

Published 8 February 2005 in Bioorg Med Chem, 13(5): 1531-6.
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