MRSA Research Today is a free monthly online journal that collates and summarizes the latest research about MRSA, including details on methicillin-resistant staphylococcus aureus, hospitals, infection, antibiotic resistance, superbugs.

5-Alkylresorcinols from Merulius incarnatus.

Jin W, Zjawiony JK

Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848.

Two new, 5-heptadeca-8'Z,11'Z,16-trienylresorcinol (1) and 5-heptadeca-9'E,11'Z,16-trienylresorcinol (2), and six known 5-alkylresorcinols (3-8) were isolated from the mushroom Merulius incarnatus. Compound 2 is the first 5-alkylresorcinol derivative that contains a trans-cis conjugated double bond system. Compounds 1, 2, 5, 6, 7, and 8 were found to inhibit methacillin-resistant Staphylococcus aureus (MRSA) with IC(50) values of 2.5, 15, 9.5, 8.0, 5.0, and 6.5 mug/mL, respectively. Compound 1 was also active against leishmania, with an IC(50) value of 3.6 mug/mL, and showed no cytotoxicity in our Vero cell test up to a concentration of 25 mug/mL. The structures of these isolates were determined by spectroscopic data including 1D and 2D NMR.

Published 28 April 2006 in J Nat Prod, 69(4): 704-6.
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