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In vitro activity of daptomycin against methicillin-resistant Staphylococcus aureus, including heterogeneously glycopeptide-resistant strains.

Diederen BM, van Duijn I, Willemse P, Kluytmans JA

Laboratory of Microbiology and Infection Control, Amphia Hospital, Breda, The Netherlands. b.diederen@elisabeth.nl

The purpose of the present study was to assess the in vitro activity of daptomycin against a well-defined collection of methicillin-resistant Staphylococcus aureus (MRSA) isolates (n = 98), including heterogeneously glycopeptide-resistant MRSA (hGISA) strains. Susceptibility testing was performed by using the Etest system. Daptomycin was potent against both glycopeptide-susceptible and hGISA strains.

Published 30 August 2006 in Antimicrob Agents Chemother, 50(9): 3189-91.
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