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Complete blindness after optic neuropathy induced by short-term linezolid treatment in a patient suffering from muscle dystrophy.

Azamfirei L, Copotoiu SM, Branzaniuc K, Szederjesi J, Copotoiu R, Berteanu C

Department of Intensive Care, University of Medicine and Pharmacy Targu-Mures, Romania. lazamfirei@orizont.net

We present a case of severe optic neuropathy following linezolid treatment, which led to complete irreversible blindness, in a patient with progressive muscular dystrophy, treated with linezolid for 16 days for methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. Interruption of antibiotic therapy did not lead to remission of ocular symptoms. Administration of linezolid may lead to severe neuropathy even in the case of short-term treatment.

Published 2 April 2007 in Pharmacoepidemiol Drug Saf, 16(4): 402-4.
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