MRSA Research Today is a free monthly online journal that collates and summarizes the latest research about MRSA, including details on methicillin-resistant staphylococcus aureus, hospitals, infection, antibiotic resistance, superbugs.

In Vivo Efficacy of a Novel Oxazolidinone Compound in Two Mouse Models of Infection.

Gill CJ, Abruzzo GK, Flattery AM, Misura AS, Bartizal K, Hickey EJ

Department of Infectious Diseases, Merck Research Laboratories, Rahway, New Jersey 07065.

A novel oxazolidinone, AM 7359, was evaluated in two mouse models of Staphylococcus aureus infection. AM 7359 and linezolid were equally efficacious in an MSSA organ burden and an MRSA localized infection model. However, AM 7359 was eightfold more efficacious than linezolid against a linezolid and methicillin-resistant S. aureus strain in this localized (thigh) model.

Published 3 July 2007 in Antimicrob Agents Chemother.
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