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Diminished vancomycin and daptomycin susceptibility during prolonged bacteremia with methicillin-resistant Staphylococcus aureus.

Bennett JW, Murray CK, Holmes RL, Patterson JE, Jorgensen JH

Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA. jason.bennett@amedd.army.mil

An elderly patient with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia was treated sequentially with vancomycin plus rifampin then daptomycin plus gentamicin. The MRSA strain developed diminished susceptibility to vancomycin (MIC increase and tolerance), daptomycin, and gentamicin, and resistance to rifampin during therapy.

Published 17 March 2008 in Diagn Microbiol Infect Dis, 60(4): 437-40.
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